Effects of Remote Ischaemic Preconditioning in Cemented Total Hip Arthroplasty: Randomized Controlled Trial
Status: Recruiting
Location: See location...
Intervention Type: Procedure, Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
Total joint arthroplasty is one of the best treatment options for end-stage osteoarthritis. Cemented hip arthroplasty is mainly indicated for elderly patients with poor bone quality and multiple comorbidities. Bone cement implantation syndrome is associated with cemented hip arthroplasty and it has been shown to increase cardiovascular and renal complication and brain damage postoperatively. The aim of this project is to elucidate whether remote-ischemic preconditioning (RIPC) has multi-organ protective effect in cemented hip arthroplasty patients.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 65
Maximum Age: 90
Healthy Volunteers: f
View:
• age \>65 years
• undergoing total hip cemented hip arthroplasty
Locations
Other Locations
Estonia
University of Tartu
RECRUITING
Tartu
Contact Information
Primary
Kaspar Tootsi, PhD
kaspar.tootsi@kliinikum.ee
+372 7318282
Backup
Kaarel Ernits, MD
kaarel.ernits@kliinikum.ee
Time Frame
Start Date: 2024-03-20
Estimated Completion Date: 2027-03
Participants
Target number of participants: 200
Treatments
Sham_comparator: Control group
SHAM procedure is done one hour before cemented hip arthroplasty and comprises of 4 cycles of 5min sham procedure. Everything apart from the pressure in the cuff is similar to the RIPC procedure.
Active_comparator: Remote Ischemic preconditioning group
RIPC procedure is done one hour before cemented hip arthroplasty and comprises of 4 ischemia (using brachial cuff with suprasystolic blood pressure for 5 min) and reperfusion (5 min) cycles.
Related Therapeutic Areas
Sponsors
Leads: University of Tartu